A bittersweet buddy movie with an improbable modifier: wine and wine-making. And it had better work, because there’s nothing else remotely refreshing for miles around. Miles (Paul Giamatti) s a dumpy, neurotic writer who’s defined by midlife crisis. Jack (Thomas Haden Church) is a two-bit actor of egregious venality who’s about to get married before it’s too late. Miles’ present to Jack is a trip through California wine country. Director Alexander Payne (“Election,” “About Schmidt”) got the title right: his movie is a downbeat lateral with spasms of quirky humor generated mostly by sexual misfires. Vulnerability and superficiality — the values Miles and Jack forcibly embody — are intended to equal a kind of charm, or to invite compassion. But dislike the men and you dislike the movie, no offense to Giamatti and Church, who act well. Your call.